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Mariana C. Baserga, MD Assistant Professor

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• Colegio Esclavas del Sagrado Corazon de Jesus, Buenos Aires, Argentina - BA

• Universidad del Salvador. Buenos Aires, Argentina - MD

• Hospital Britanico de Buenos Aires, Buenos Aires, Argentina - Residency (Pediatrics)

• University of California - San Francisco, San Francisco, CA - Fellow (Cardiovascular Research

• Cedars-Sinai Medical Center, Los Angeles, CA - Post-Doctoral Fellow

• Cedars-Sinai Medical Center Los Angeles, CA - Neonatal Fellowship

• Children's Hospital of Orange County, Orange, CA - Residency (Pediatrics)

• American Board of Pediatrics (Pediatrics)

• American Board of Pediatrics (Sub: Neonatal-Perinatal)

• Assistant Professor - University of Utah, Department of Pediatrics

• National Institues of Health Iugr Affects Renal 11Beta-Hsd2

• Primary Childrens Medical Center Fndtn IUGR Affects Renal Gene Expression and Subsequent Phenotype in Rats

• Uteroplacental insufficiency affects kidney VEGF expression in a model if IUGR with compensatory glomerular hypertrophy and hypertension.
  Baserga M, Bares AL, Hale MA, Callaway CW, McKnight RA, Lane RH
  Early Hum Dev

• Uteroplacental insufficiency alters nephrogenesis and down regulates cyclooxygenase-2 expression in a model of IUGR with adult onset hypertension.
  Baserga MC, Hale MA, Wang ZM, Yu X, Callaway CW, McKnight RA, Lane RH
  Am J Physiol Regul Integr Comp Physiol

• Uteroplacental insufficiency increases p53 phosphorylation without triggering the p53-MDM2 function circuit response in the IUGR rat kidney.
  Baserga M, Hale MA, Ke X, Wang ZM, Yu X, Callaway CW, McKnight RA, Lane RH
  Am J Physiol Regul Integr Comp

• Uteroplacental Insufficiency Alters Hepatic Expression, Phosphorylation and Activity of the Glucocorticoid Receptor in Fetal IUGR Rats
  Mariana Baserga, Merica Hale, Robert A. McKnight, Xing Yu, Christopher W. Callaway, Robert H. Lane
  Am J Physiol Regul Integr Comp Physiol

• Multifocal Castleman Disease in Pediatrics: Case report.
  Baserga M, Rosin M, Shoen M, Young G
  Am J Pediatr Hematol Oncol, 666-669

Dr. Baserga's research focuses on the molecular mechanisms of fetal origins of adult disease. More specifically, her interest has been to determine how intrauterine growth restriction leads to adult onset of disease, in particular hypertension. Using an animal model of uteroplacental insufficiency in rats that has been shown to affect nephron number, she is investigating the apoptotic and glucocorticoid signaling pathways. Currently Dr. Baserga is working to test the hypothesizes that intrauterine growth restriction alters renal determinants of cell prolferation and death by interfering with signaling of p53,11 beta-Hydroxysteroid type 2, the glucocorticoid receptor and COX-2.